Dear Sir,
This is Thirunavukkarasu am working in Ordain Health Care
AR&D, Am Having one problem While doing method development
my question Metadoxine and Pyridoxine same chemical nature
and structural activity i tried lot of methods but Analyte
eluted same Retantion time i cant separate both peaks.
solubility, pH both are same only only difference melting
point metadoxine 210 C Pyridoxine 102 C please do the help
needful for me
- 5 Answers
- 8123 Views
- Ordain Solutions, I also Faced
- E-Mail Answers
Answer Posted / a.prabhakar
Dear Thirunavukkarasu,
What is your column flow rate and have you change column flow rate.
| Is This Answer Correct ? | 2 Yes | 1 No |
Post New Answer View All Answers
What is the difference between Discriminating media and DPDM(Dissolution Profile with Different Media)
In rs method development when we are going area normalization method to dilute standard method?
How to choose the which salt is suitable for mobilephase
What is the difference between purge septum flow and column flow in gas chromatography?
why multimedia dissolution require to do?
WHICH STANDARD WE USE IN SILICA ANALYSIS IN SILICA-GEL METHOD FOR SOLID SAMPLE
why we use a particular hplc column for a particular compound give reasons?please
can we use the same detector in HPLC as well GC and what could be the differences we can find in the final chromato graph in any aspects?
While performing TOC sst analysis Zero shift disabled & sample analysis zero shift enabled why?
on saturation solubility study data how we can find out the bcs class of drug?
Why do we use KMnO4 in the test of control of obsorbance ? and why do we take specific quantity i.e 57-63mg?
What is related substance by HPLC impurity limits as per USP?
how will you do the prep for unstable componds?
For titration in anhydrous media with perchloric acide, if lack of titrator, Which indicator is been used for replacement. How calculate pH of test solution to choose suitable indicator?
What is the calibration of uv process and preparation
