why the most API molecule are in the hydrochloride form?
Answer Posted / mr.shoukatalli naikwade
API molecule without hydrocloride salts are in the form of
base and it is higly non polar.its solubility in water as
well as in our blood and gastric juices in stomach is very
poor.
Our pH of stomach is arround 2 and gastric acid consisting
mainly of hydrochloric acid 0.5%.
To increase API's solubility of drugs,salt formation plays
important role in dissolution and dis integration of tablet.
for salt formation hydrochloric acid is mostly choosed.
Is This Answer Correct ? | 27 Yes | 0 No |
Post New Answer View All Answers
what is mean by 40 in the dissolution basket mesh size?
Why only Copper standard is used to calibrate Atomic Absorption spectrophotometer?
If we have 5 strength which is not dose proportinate and excipients also diffrent in each strength then how we can proceed for Force degradation? and excipient are same but not dose propotinate the how FD?
what is the procedure for cleaning of lenses of hatr accesory of ftir instrument?
how much mass should be there in volumetric flask while in preparation of sample for assay?
how require to select dissolution media? what is discrimination?
What are modes of quantification in related substances
How to fix the sample conc. in Related substances test by HPLC?
In the HPLC Calibration done wavelength accuracy done between 200nm-280nm .but not done remaining 300-400nm not done ?
What is viod volume and peak purity in HPLC?
why holium oxide prepared in 10% HCLO4 SOLUTION
How to determine water content of bis tetrazole amine mono ammonium salt
What is the Formula for coreletion coefficient in plhplc calibration
What is the formula to determine the concentration of M of a solution given the % transmittance? Use %T = 43.7 as an example.
What is shaking level in GC?