Answer Posted / m.balram naidu
BUFFERS IS USED TO DEPAND UP ON THE DRUG PKa VALUES
BUFFERS PH IS ALLWAYS (+) OR (-)1
BECAUSE IS USED PHASPATE OR ACETATE BUFFERS IS USED
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2. Two grams of Benzoic acid are dissolved in 200 ml of water and extracted with 200 ml of diethyl ether. The distribution coefficient of benzoic acid is 100, and its dissociation constant is 6.5 10-5. Calculate the distribution ratio (D) of benzoic acid at pH 2, 5, and 6. 3. Calculate D at pH 2 to 10 (1 unit apart) in the above problem, and plot D versus pH.
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