Interested to Buy Any Domain ? << Click Here >> for more details...
In the method validation proceedure,lod & loq calculation we use the formulae for LOD=3.3*SD/slope and for LOQ=10*SD/slope,why we use 3.3 & 10 in the formulae?
- 1 Answers
- 10916 Views
- I also Faced
- E-Mail Answers
Answer Posted / veeru01
LOD :- LOD is measured 10 times independent sample of Blank
and Student-t test of 10 times, Degree of freedom 9 (n-1)at
99% confidence label is 3.25 as per Student chart. Also
Ratio of S/N =3:1
LOQ:- LOD is regarded as the lower limit for precise
quantitative Measurement . LOQ defined as concentration
which would a produce a signal 10-12 time. At this point
standard deviation is small enough (Approximately 10-15%) so
that quantified value can be deemed reliable. Also Ratio
S/N= 10:1
| Is This Answer Correct ? | 7 Yes | 3 No |
Post New Answer View All Answers
How do we quantify crystaline and amarpous forms by using (NMR, XRD)spectroscopic techniques? Which any others instruments are useful for this quantification? explain
Why only hydroxy naphthol blue indicator is used for standardisation of 0.05M EDTA solution instead of solochrome Black T or Euriochrome Black T indicator which is used for all sample analysis with 0.05M EDTA solution?
in dissolution why pool sample needed? in which type of drug pool sample need?
What are modes of quantification in related substances
What is control room temperature and which guide line says?
From where require to take the RLD sample?
how you fix the limits of impurities?
What is dose dumping? why require to do?
in hplc chromatogram started from left to right and in uv spectrum started from left to right
4. Describe the operation of the Craig apparatus. Chapter.3 Equilibrium Processes in Separations
Why irmoisture balance is used for corrugated box moisture testing
from where i get mortar pastle for glass bottle crush? it's required for testing of it?
If we have 5 strength which is not dose proportinate and excipients also diffrent in each strength then how we can proceed for Force degradation? and excipient are same but not dose propotinate the how FD?
is it necessary to do HPLC calibration at wavelength 315nm if we are doing analysis at this wavelangth
2. Two grams of Benzoic acid are dissolved in 200 ml of water and extracted with 200 ml of diethyl ether. The distribution coefficient of benzoic acid is 100, and its dissociation constant is 6.5 10-5. Calculate the distribution ratio (D) of benzoic acid at pH 2, 5, and 6. 3. Calculate D at pH 2 to 10 (1 unit apart) in the above problem, and plot D versus pH.
