dr. virendra kumar arya


{ City } bhiwadi
< Country > india
* Profession * qc manager
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Questions / { dr. virendra kumar arya }
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In HPLC Chromatographic separation Resolution equation is Rs = 1.18 (tR2 –tR1)/wh1+Wh2, Where, tR2 and tR1 is run time of eluent ratios of the distances from the point of application to the centers of the spots and the distance travelled by the solvent front from the point of application (retardation factor), and Wh1and Wh2 , is peak width of at half height. What is 1.18 ?

1 Analytical Chemistry 6238

what is difference between drug products and drug substance?

DRL,

5 Analytical Chemistry 89409



Answers / { dr. virendra kumar arya }

Question { 16487 }

Why Deuterium lamp is used as UV light Source for UV.


Answer

Deuterium lamp generate UV Radiation (190 nm to 380 nm). In
this radiation rang all product (organic and in-organic)
absorbe light and electrons exit from its ground state to
transition, resultant give absorbance w.r.t specific
wavelength of product ʎ max.

Is This Answer Correct ?    10 Yes 0 No

Question { 10074 }

In the method validation proceedure,lod & loq calculation we use the formulae for LOD=3.3*SD/slope and for LOQ=10*SD/slope,why we use 3.3 & 10 in the formulae?


Answer


LOD :- LOD is measured 10 times independent sample of Blank
and Student-t test of 10 times, Degree of freedom 9 (n-1)at
99% confidence label is 3.25 as per Student chart. Also
Ratio of S/N =3:1
LOQ:- LOD is regarded as the lower limit for precise
quantitative Measurement . LOQ defined as concentration
which would a produce a signal 10-12 time. At this point
standard deviation is small enough (Approximately 10-15%) so
that quantified value can be deemed reliable. Also Ratio
S/N= 10:1

Is This Answer Correct ?    7 Yes 3 No