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Answer / lava khandelwal
MACO = Maximum Allowable Carryover (MACO), its limit could
be establish as below:
TDDprevious x MBS
MACO = ------------------------------
SF x TDDnext
MACO Maximum Allowable Carryover: acceptable transferred
the investigated product ("previous")
|Is This Answer Correct ?||7 Yes||0 No|
Maximum Allowable Carryover (MACO)is the limit of previous product in next product during cleaning validation.
can be calculated by the formula-
TD x BS xSF
MACO = ----------------
TD: single therapeutic dose of product A
BS : bach size of product B(minimum batch size)
SF: safety factor(1/1000) or 0.001
LDD : largest daily dose of product B
|Is This Answer Correct ?||3 Yes||0 No|
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