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what do you mean by MACO
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Answer / lava khandelwal
MACO = Maximum Allowable Carryover (MACO), its limit could
be establish as below:
TDDprevious x MBS
MACO = ------------------------------
SF x TDDnext
MACO Maximum Allowable Carryover: acceptable transferred
amount from
the investigated product ("previous")
Thanks
Lava Khandelwal
08650002470
| Is This Answer Correct ? | 8 Yes | 0 No |
Maximum Allowable Carryover (MACO)is the limit of previous product in next product during cleaning validation.
can be calculated by the formula-
TD x BS xSF
MACO = ----------------
LDD
where,
TD: single therapeutic dose of product A
BS : bach size of product B(minimum batch size)
SF: safety factor(1/1000) or 0.001
LDD : largest daily dose of product B
| Is This Answer Correct ? | 4 Yes | 0 No |
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