Answer / lava khandelwal

MACO = Maximum Allowable Carryover (MACO), its limit could
be establish as below:

TDDprevious x MBS
MACO = ------------------------------
SF x TDDnext

MACO Maximum Allowable Carryover: acceptable transferred
amount from
the investigated product ("previous")

Thanks
Lava Khandelwal
08650002470

Answer / amit chauhan

Maximum Allowable Carryover (MACO)is the limit of previous product in next product during cleaning validation.
can be calculated by the formula-

TD x BS xSF
MACO = ----------------
LDD

where,
TD: single therapeutic dose of product A
BS : bach size of product B(minimum batch size)
SF: safety factor(1/1000) or 0.001
LDD : largest daily dose of product B

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