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WHAT IS FORCED DEGRADATION STUDy?
HOW TO PERFORM FORCED DEGRADATION ON TABLET SAMPLE OR
SUSPENSIONS?
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Answer / kanakadurga
under specificity forced degradation study is performed.
specificity is the ability to asses unequally the analyte in
the presence of components which may be expected to be present.
FORCED DEGRADATIION:
It is performed by following tests.
Heat:At about 105"c for about6 hours.
Humidity:About 90% RH at 25'c for not less than 7 days.
Uv light:Not less than 7 days in uv cabinet or 200 watt
hours or in photostablity chmber.
Sunlight:Not less than 55 hours in sunlight or 1.2million
lux hours in photostability chmber.
Acid:0.1 N HCL reflulxed for 30 minutes at 60"c.
Base:0.1N NAOH refluxed for 30 minutes at 60"c
Peroxide:1% H2O2 refluxed for 30 minutes at 60"c.
Water:refluxed for 6hours at 60"c
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