How to fix the concentration for RS by HPLC
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Answer Posted / mahesh
What if the impurity limit is 2%?
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In BP2013, Loperamid HCl monograph. Assay by titration with 0.1N sodium hydroxide using hydrocloric acid 0.01N and reading the volume added between the 2 points of inflexion. I have a question that if the diluent solvent is ethanol is certainly consumed a amount of volume of titrant, so this volume must be eliminated on the result calculation or not apart from first point which is subtracted above.
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In the isomers,enantiomers give the only physical properties present such that no chemical properties present.
