How to calculate LOD & LOQ in HPLC Validation Method
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Answer Posted / nikhil gandhi
Based on ICH Guideline there are many method given to
identify LOD and LOQ, but most useful method is slope and
residual standard deviation is used.
LOD : 3.3 X sigma/ Slope
LOQ : 10 X sigma/ Slope
Sigma : Residual Standard Deviation
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