How can we konw that the HPLC column is endcapped? Is it
possible to identify visually without COA?
Answer Posted / subash
The column without endcapping increses silanol activity due
to residual silanols. To know the column is encapped inect
the amytriptyline a basic compound in to the column which
gives the information about peak tailing. If tailing is
more means more silanol activity.
| Is This Answer Correct ? | 8 Yes | 1 No |
Post New Answer View All Answers
Why are use silicon oil mr?
Qc interview questions
What is related substance by HPLC impurity limits as per USP?
How require to perform linearity as per ANVISA? What are the acceptance criteria?
is it nessesary to do solution stability for 7 days?
How you develop a method in HPLC?
WHAT IS THE USE OF STARTER ?????????
what type of question will ask in the interview of lab chemist.
why require the ph, buffer during hplc mobile phase?
we are performed SOR for a particular product the limit is -6 to -10.We face particular bathes it is not meeting the specification.we performed diffrent instrument diffrent analyst we are getting diffrent diffrent results.solvent is dimethyl sulfoxide what could be the reasion
How to set analyticl specification for combination products?
How to determine water content of bis tetrazole amine mono ammonium salt
If we have 5 strength which is not dose proportinate and excipients also diffrent in each strength then how we can proceed for Force degradation? and excipient are same but not dose propotinate the how FD?
Why do we use KMnO4 in the test of control of obsorbance ? and why do we take specific quantity i.e 57-63mg?
How to decide assay range for non pharmacopeial API analysis by HPLC? Could you give me any reference for same e.g Guidelines or Paper publications?