How the NUCLEOSIDE ANALOGUES ARE USED AS DRUGS?
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Answer Posted / spandana
Nucleoside analogues 3'azidodeoxythymidine and
2',3'-dideoxycytidine used for the treatment of AIDS.when it
is given to aids patients ,azt and ddcare converted into
triphosphate forms which compete with dttp and dctp as
substrates for dna synthesis.as dna synthesising enzymes of
hiv are sensitive to azt and ddc inhibition these
nucleoside analogues acts as drugs for hiv patients.
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