Answer Posted / deepika hemant bankhede

A Quantitative chemical reaction between water and
Anhydrous SO2 and Iodine in the presence of Base(buffer)
that reacts H+.And the amount of water present in the sample is calculated
based on the concentration of iodine in the Karl Fisher
titrating reagent (i.e., titer) and the amount of Karl
Fisher reagent consumed in the titration. and the amount of Karl
Fisher reagent consumed in the titration. Macanism of action- H2O+I2+SO2+CH3OH+3RN=[RNH]SO4CH3+2[RNH]I

why require to do water content for drug product?

812

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Ph meter can show more than 14 ph reading? Why ph range in between 1 to 14 only?

720

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Why only hydroxy naphthol blue indicator is used for standardisation of 0.05M EDTA solution instead of solochrome Black T or Euriochrome Black T indicator which is used for all sample analysis with 0.05M EDTA solution?

2702

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why we are using hexane in calibration of number of drop per mL

1717

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in dissolution if one bowl got 70 percent 2nd bowl got 80 percent and 3rd bowl got 90 percent then how proceed?

738

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How to set analyticl specification for combination products?

718

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what is partion and column chromatography

2368

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if your product is soluble in 0.1n hcl and water then which you choose as media from these 2 media?

666

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What is rs test why we are performing rs test?

1838

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AT WHAT CONDITIONS WILL YOU ANALYSE A SAMPLE,WHICH ARE PRESERVED AT OTHER THAN THE AMBIENT CONDITIONS?(ie COLD STORAGE SAMPLES BELOW 20* CENTIGRADE?

2037

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effect of pore size, pore volume, partical size, column length, carbon load on retention time? what is carbon load? what is the use?

895

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in dissolution why pool sample needed? in which type of drug pool sample need?

3165

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From where require to take the RLD sample?

744

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how you start RS method development when for new product?

702

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WHAT IS THE USE OF STARTER ?????????

2397

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