Answer Posted / chmreddy

A good electrode has a mV of 0 ± 30 mV in pH 7.
The slope should be 90 to 105%.
Example:
Readings
pH 4 : 4.29
pH 7 : 7.43
Convert pH 7 reading to mV
7 – 7.43 = -0.43 pH * 59.16 mV/pH = -25.44 (this value is okay because it is within 0 ± 30mV)
Convert pH 4 reading to mV
7 – 4.29 = 2.71 pH * 59.16 mV/pH = 160.32
Calculate slope
160.32 – (-25.44) = 185.76 mV/ 177.48 mV * 100 = 105 %
(this value is borderline as 105% is the upper limit)

Tell me about analytical method validation in QC

6175

---

How would you decide dissolution medium for NCE compound of class I drug

2254

---

What is the diffrence in japan mkt requirement in analytical method validation over US?

719

---

if content uniformity passing but dissolution varrying then what is next step?

875

---

WHAT IS THE CRITERIA FOR SELECTION OF TIME OF DISSOLUTION AND THE MEDIUM OF DISSOLUTION?

2576

---

If vendor having more imp than monograph then how to proceed? and how to set spec?

926

---

Why potassium dichromate is used in calibration of uv?

1983

---

What is the acceptance criteria for moisture balance when calibrated with sodium sulfate

2038

---

what is impurity profile. how to interpret this impurity profile to a drug product or drug substance.

2629

---

Qc interview questions

1740

---

how require to fix the linearity and accuracy cincentration range?

1664

---

How to determine water content of bis tetrazole amine mono ammonium salt

3484

---

which are the sizes of capsules?

964

---

What is the requirement for brazil in the analytical method vslidation comparr to ich?

779

---

all types of questions asked at the cipla interview

4680

---