Answer Posted / ankur dwivedi

Most substances are easily soluble in these solvents. They have lower absorbance in routine HPLC working range (205-400 nm). Hence no interference will be there due to these solvents.
Due to less density, they create less pressure in column and hence the column life can be improved.

analytical method validation require to with respect to release specification or shelf life specification?

734

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Why only hydroxy naphthol blue indicator is used for standardisation of 0.05M EDTA solution instead of solochrome Black T or Euriochrome Black T indicator which is used for all sample analysis with 0.05M EDTA solution?

2668

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what parameters we will consider while developing a HPLC method and how we confirm our HPLC method is valid?

3631

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[3/30, 13:29] Manoj P Venkatpurwar: How hplc column selection according to structure? How mobile phase buffer selection on molecule structure?

711

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What is similarity factor?

1148

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could negative ions be produced by bombardment process in mass spectrometry?

1724

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1)What's the meaning of Absorption,give a example. 2)What's the meaning of Adsorption,give a example. 2)what is the difference between Absorption and Adsorption.

2832

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some product having water content method with pyridine and ethylene glycol mixture instead of methanol? how they are selecting and methanol is not suitable solvent how ?

2600

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WHICH STANDARD WE USE IN SILICA ANALYSIS IN SILICA-GEL METHOD FOR SOLID SAMPLE

2079

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how you confirm the assay method?

726

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In which situation we require to prepare the standard solution from sample in Related substance method?

714

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What is the diference between residual solvents and organic volatile matter

1964

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What should be the level/ Percentage of Arsenic in Arsenic free zinc.

2180

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what is the structure of DOWEX-50

5454

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[3/28, 20:52] Manoj P Venkatpurwar: how many impurities require to inject in assay specificity that how we can find out? and in Rs also how?

748

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