Answer Posted / venkatanarayana

Leak test,System Precision , Detector Linearity

How to determine the EDTA content by potentiometry titration in Ceftriaxine sodium

2546

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How to calculate coreletion coefficient

1713

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How can I develope method of dissolution by HPLC OR UV

2408

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how to develop the icp ms method? Application of icp ms?

812

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in which situation ion pair agent require to use?

739

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In HPLC calibration, caffeine is used as primary standard for wave length calibration due to caffeine is having dual maxima at 273 & 205 nm and one minima at 245 nm. Any body can give reference of these details from any pharmacopeia (with chapter no.) or any other authentic guideline?

1973

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How require to perform linearity as per ANVISA? What are the acceptance criteria?

1336

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WHAT IS THE PURPOSE WE USE HCL, CHOPPER, BURNER, MONOCHROMATOR in AAS? PLEASE EXPLAIN BRIEFLY

2608

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How would you decide dissolution medium for NCE compound of class I drug

2258

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WHY pKa value is more important than pH value of the mobile phase in HPLC?

1769

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what is lod and loq ?,why use k2cr2o7 , kcl h2so4 in uv calibration ?,why use benzophenone & caffene acetone in hplc calibration ?,what is leading peak in hplc ?why we do the calibration of limit of stry light in hplc & uv ?

3669

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If change in specification which parameter require to do for validation? if change in chromtographic condition then which parameter? if api change then which parameter? if change composition then which parameter? if old method not work out then whicj parameter? if additional one impurity added then which parameter of validation require to do on above each conditions? elaborate separately

856

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how we can identify the impurity is coming below loq at transfering site?

872

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In Dissolution Test why limit is define Q+5% what is the role of +5%.

3104

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how a particular wavelength can be different for a particular compund while analysing by uv and by HPLC.

2300

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