Interested to Buy Any Domain ? << Click Here >> for more details...
What is the reason for using the 900ml of dissolution medium
- 16 Answers
- 79613 Views
- Cipla, I also Faced
- E-Mail Answers
Answer Posted / swayamprakash patel
I laughed lot after reading all stupid answers...
Any ways...
whole criteria of selecting volume of tablet dissolution is
SINK CONDITION.
One have to select dissolution media from normal
physiological pH range. Moreover, volume of dissolution
media must create sink condition.
For creating sink condition, volume of media must be at
least 3 times (or more than 3) the maximum dose/solubility
ratio of drug.
For most of drug 900 ml fulfill this criteria. However there
are some drug which need 1000ml (eg:Fenofibrate). while for
some drugs 500ml is enough.
That is what exactly the reason.
Need further clarification: go to following link
http://www.dissolutiontech.com/DTresour/201211Articles/DT201211_QA.html
Volume of stomach is more than 900 ml...But this answer is
totally stupid...I mean how many patients drink about a 1
liter water with single tablet?....HA HA HA...
| Is This Answer Correct ? | 41 Yes | 11 No |
Post New Answer View All Answers
how to decide for one product require water content or LOD?
how you start RS method development when for new product?
What is the difference between purge septum flow and column flow in gas chromatography?
before starting analytical method valodation what you checking? and how giving preference to start validation?
How require to perform linearity as per ANVISA? What are the acceptance criteria?
pharma industries oriented
what is lod and loq ?,why use k2cr2o7 , kcl h2so4 in uv calibration ?,why use benzophenone & caffene acetone in hplc calibration ?,what is leading peak in hplc ?why we do the calibration of limit of stry light in hplc & uv ?
Why irmoisture balance is used for corrugated box moisture testing
in OSD forms require to use gas chromatography?
could negative ions be produced by bombardment process in mass spectrometry?
why should we perform dissolution PVT calibration only by UV spectrometer, not by HPLC ?
effect of pore size, pore volume, partical size, column length, carbon load on retention time? what is carbon load? what is the use?
AT WHAT CONDITIONS WILL YOU ANALYSE A SAMPLE,WHICH ARE PRESERVED AT OTHER THAN THE AMBIENT CONDITIONS?(ie COLD STORAGE SAMPLES BELOW 20* CENTIGRADE?
why we use Dichlorobenzene.nitrobezine.t-butyldi sulhate.for calibration of gc Head space
How require to develop GC method? how to select diluent, GAS, column selection and other chromatographic conditions?
