Answer Posted / bhargav
Purity:
It is calculated by area normalisation method, it can be
directly find out by chromatograms obtained from HPLC.
% Purity = (Area of desired peak / Sum of area of all
peaks) x 100
Assay:
It is calculated against standard. It may be of following
types:
1) On as is basis = (Area of sample / Area of standard) x
(conc. of standard / conc. of sample) x potency or assay of
standard
2) On anhydrous basis = (Assay on as is basis / 100 –
moisture) x 100
3) On dried basis = (Assay on as is basis / 100 – LOD) x 100
Potency:
100 – (moisture or LOD + residual solvents + heavy metals
+ sulphated ash + impurities)
| Is This Answer Correct ? | 17 Yes | 2 No |
Post New Answer View All Answers
What is diffrence between extractable volume and deliverable volume? Answer pls
In Assy by potentio metry titration method how select MET U ,DET U, SET U,
Why irmoisture balance is used for corrugated box moisture testing
can we use the same detector in HPLC as well GC and what could be the differences we can find in the final chromato graph in any aspects?
Why we use potassium dichromate in uv calibration Exact reason behind it??
If inhouse hplc related substance method is completly diffrent from Usp for finished proďuct with diffrent impurities then how require to prove method equivalecy?
CAN WE DETERMINE THE PEAK PURITY IN GAS CHROMATOGRAPHY ANALYSIS?
What is control room temperature and which guide line says?
What is the requirement for brazil in the analytical method vslidation comparr to ich?
Why we select scan range from higer wavelength to lower wavelength in uv visible spectroscopy and ftir spectroscopy ? .
What is similarity factor and its use in api strength?
Why potassium dichromate is used in calibration of uv?
in gas chromatography what is the difference between gas flow rate and average linear velocity ?
which batch require to use for analytical method validation?
if you get peak in blank then what require to do?
