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how can we determine RRF value in HPLC FOR CALCULATION OF
IMPURITY ?
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Answer Posted / godhani pragnesh
RRF= Relative response factor (Impurity response with
respact to main peak)
RF= Response factor (the response (e.g. peak area) of drug
substance or related substances per unit weight.
RF= peak area / concentration (mg/ml)
Relative response factor (RRF)calculation:
RRF=RF impurity / RF API
OR
RRF=slope impurity / slope API
| Is This Answer Correct ? | 42 Yes | 6 No |
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