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What is difference between Chromatographic purity and
Related substances analysis?
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Answer Posted / arumugam
chromatographic purity is %area normalization is nothing
but Impurity area/Major compound area, applicable for all
known and unknown impurities.
But Related substances is quantification of all impurities
nothing but the impurities are quantified by know
concentration of standard solution.
Impurity (%w/w)= Imp area* Std. Dilution*Potency of Std*RRF
------------------------
Std Area* sample Dilution
RRF= Relative Response factor
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