Answer Posted / sunil.madhukar rao kulkarni

We can calculate LOD and LOQ values using linearity
graph,insted of sigma value STEYX can be considered for
more acuurate vale of LOD and LOQ

where STEYX : Standard error of the pridected Y-value for
each X in a regression

Final calulation given as below :

LOD = STEYX x 3/ Slope

LOQ = STEYX x 10 /Slope

how you establish the LOQ?

841

---

What is the purpose of octyl silane columns?

4335

---

what is mean by nitrosamine impurities?

1115

---

WHAT IS THE PARAMETER FOR THE SELECTION OF MOBILE PHASE IN HPLC?

1248

---

what is %labelled amount in content uniformity of dosage unit and its calculation?

5299

---

can i use hplc detector to uplc and why?

2347

---

What is the difference between Discriminating media and DPDM(Dissolution Profile with Different Media)

7596

---

if tech transfer fails whay require to do?

892

---

we are performed SOR for a particular product the limit is -6 to -10.We face particular bathes it is not meeting the specification.we performed diffrent instrument diffrent analyst we are getting diffrent diffrent results.solvent is dimethyl sulfoxide what could be the reasion

1919

---

for which product require to do content uniformity? what is limit of cu?

867

---

what is mean by ambient temperature?

973

---

What is the difference between purge septum flow and column flow in gas chromatography?

2643

---

1.What is the difference between method validation and method verification 2.Which guidelines proposed to method transfer

1900

---

what are the guidelines for analytical method validations?

1148

---

Related substance method equivalency on control sample or spiked sample?

821

---