Answer Posted / balaji

There are three different method indiated in ICH guidelines
for determination of LOD and LOQ.

1 Visual evaution method - For non instrument and sometimes
for instrumental also.

2 Slope Method:Based on residual standard deviation of the
response and
the slope
obtained will be calculated as:

Limit of Detection (LOD):
DL= 3(RESIDUAL SD/Slope)


Limit of quantification(LOQ):
DL=10(RESIDUAL SD/Slope)

3 Signal to noise ratio method
Limit of Detection (LOD):
S/N NLT 3

Limit of quantification(LOQ):
S/N NLT 10
Slope and S/N methods are more reliable
method for determination of LOD and LOQ value

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