Answer Posted / hari prasad

LOD means Sample concentration whereever gets the lowest
detection and there sample has not quantified.

LOQ means Sample concentration whereever gives lowest
quantified detection and there sample has quantified.

The LOD&LOQ concentration where the precission %RSD would
have 'not more than 30% and 10%' respectively, those are
the finalised LOD and LOQ limits to report.

Now impurities can report based on established LOD&LOQ
limits i.e. Not detected or below LOQ.

what is the principle involved in turbidometry and nephelometry ?

4110

---

For standardization of volumetric solutions, acceptance limit for concentration is considered as 10% of nominal concentration and %RSD as NMT 0.2% (for appropriate no. of replicates). But , if %RSD has not met, what should be further action?

1836

---

How can we calculate "confidence interval" in analytical method validation? Pl. explain with example.

4150

---

Why dissolution test is not performed in all of the products

2482

---

Basic principle of ESI?

2096

---

why we use Dichlorobenzene.nitrobezine.t-butyldi sulhate.for calibration of gc Head space

2203

---

what is the disso medium for tropsiun chloride

2212

---

what is definition of validation? which components are followed give detail?

2292

---

if you have given one product then how you determine the impurity in that?

691

---

Hi sir if any product monograph not given known impurities (may be 5 impurities) specifications then how we require to proceed for inhouse formulation?

651

---

what you do when compound having dwel wavelength?

702

---

If we have 5 strength which is not dose proportinate and excipients also diffrent in each strength then how we can proceed for Force degradation? and excipient are same but not dose propotinate the how FD?

757

---

what is mean by dissolution biowaiver study?

851

---

What is diffrence between extractable volume and deliverable volume? Answer pls

4497

---

Why to use propyl paraben in HPLC gradient calibration

7319

---