Answer Posted / viswanadham.dama

Uniformity of dosage units are determined from two ways.

1.Content Uniformity
2.Weight variation


Content Uniformity is applied when tablet or capsules having
25mg or below and
when active pharmaceutical ingradient 25% weight present in
the total tablet weight.

weight variation test is versa.

Acceptance critiria for uniformity of Dosage units are for
content uniformity Acceptance value cannot be more than 15.

calculation of acceptance value is
A.V=(X-M)+K.S
where X=Mean value of 10 units
M=98.5 or 101.5
K=2.4(constant value) for 10 units
2.0(constant value) for 30 units
S=Standard Deviation value

in the above expression there are three cases
a)A.V=K.S(when X value lies 98.5 to 101.5)
b)A.V=(X-M)+K.S(when X value is more than 101.5)
c)A.V=(M-X)+K.S(when X value is less than 101.5)

effect of pore size, pore volume, partical size, column length, carbon load on retention time? what is carbon load? what is the use?

895

---

in which situation ion pair require to use?

794

---

how much mass should be there in volumetric flask while in preparation of sample for assay? 

2556

---

what is mean by nitrosamine impurities?

1054

---

if you have given a blank water how you analyse by general analytical techniques?

2016

---

How to calculation of residual solvent methanol (3000 ppm) standard solution, and how many quantity used of test sample

3213

---

how a particular wavelength can be different for a particular compund while analysing by uv and by HPLC.

2277

---

Is it nessesary all multimedia dissolution require descriminatory?

782

---

What are usp limits for theoritical plats,resoution,tailing factor,peak to valley ratio

1889

---

which one is better separation in high pressure liquide chromatogram orlowpressure chromato gram in hplc

2149

---

what is third integration

1961

---

why multimedia dissolution require to do?

793

---

could negative ions be produced by bombardment process in mass spectrometry?

1761

---

why require to add enzymes in capsules dissolution only? is it require to tablet also?

669

---

cefoperozone and sulbactam inj. hplc test method

2675

---