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How to calculate LOD & LOQ in HPLC Validation Method
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Answer Posted / m
There are three different method indiated in ICH guidelines
for determination of LOD and LOQ.
1 Visual evaution method - For non instrument and sometimes
for instrumental also.
2 Based on residual standard deviation of the response and
the slope
obtained will be calculated as:
Limit of Detection (LOD):
DL= 3(SD/Slope)
Limit of quantification(LOQ):
DL=10(SD/Slope)
3 Signal to noise ratio method
But residual standard deviation method is more reliable
method for determination of LOD and LOQ value
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