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Answer Posted / abdulkalim
In general Reference Standard are classified in to
1. Primary reference standard
2. Secondary reference standard/ Working standard
Primary reference standard:
--------------------------
These standard are the authentic substances with high
purity drug with critical characteristics which are
suitable for specific purpose only. It is provided through
official pharmacopeial agencies or authentic manufacturer.
Which have 100% pure durg substances.
Pharmacopeial Agencies: USPCRS, EPCRS, BPCRS
Authentic Manufacture: Standards supplied by
manufacturer/vendor which manufacture high purity
material/reagent which comprises ACS, HPLC grade,
Spectroscopic grade,IR grade,AR, etc.,
Ex: Merck, LGC-Prochem.
These are used for:
1. Standardization of Volumetric Solution.
2. Calibration standards used for calibration of anlytical
instruments/equipments.
Secoundary Reference standard:
------------------------------
There are the substances used for substitute for official
Primary reference standard used for routine analysis by
standardizing against Primary reference standard.
This is even called as "Working Standard"
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