Answer Posted / k.praveen kumar macleods pharm

If the method is linear or not from certain range suppose
in assay validation the range is 50% to 150% we are
injecting minimum 6 levels and also Calculate the regration
line the correlation coefficient should be less than 0.999
Here regration line equation is y=mx+c

where y = Regration line
m = Slope
c = Intercept.

and also calculate residual sum of squares from theorical
and practical

If we do accuracy at same concentration at which linearity planned,what is the need to do linearity separately?

2238

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in which situation ion pair require to use?

742

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How will u perform degradation study in detectors other thann PDA in HPLC Methodology

2475

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How require to perform linearity as per ANVISA? What are the acceptance criteria?

1268

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can we use the same detector in HPLC as well GC and what could be the differences we can find in the final chromato graph in any aspects?

2123

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if your product is soluble in 0.1n hcl and water then which you choose as media from these 2 media?

630

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What is viod volume and peak purity in HPLC?

2811

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what parameters we will consider while developing a HPLC method and how we confirm our HPLC method is valid?

3626

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Describe your field experience sample type collected,sample techniques,field measurements taken and equipment used?

2647

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What is diffrence between extractable volume and deliverable volume? Answer pls

4494

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Why are use silicon oil mr?

1150

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What is the requirement for brazil in the analytical method vslidation comparr to ich?

696

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what is the different in Total ash, sulphated ash, acid insoluble ash, alcoholic or non alcoholic ash?

9926

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If suppose 10 methods of dissolution given in pharmacopoeial for single content product then which method out of 10? or all 10 require to follow?

929

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What is the formula to determine the concentration of M of a solution given the % transmittance? Use %T = 43.7 as an example.

2600

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