Question { Torrent Pharma, 8468 }

Why we use basket in place of bowl in
dissolution apparatus

Answer

Basket is mainly used when the Dissolution Medium must have to get changed during the testing ( in continuation ). During the dissolution Analysis of Enteric Coated units first we use to check dissolution of the API in to the 0.1 N HCl medium in order to check any release of drug in Acid medium or not for 2 hours ( equal to gastric Emptying time ) than we changed medium to 6.8 pH phosphate buffer equal to Intestinal fluid to carry out complete dissolution of the dosage form.

Question { Lupin, 10247 }

what is the exact diff betwen the uniformity of weight &
uniformity of content?

Answer

Uniformity of Weight is carried out to get information whether the weight of individual units are having uniform weight or not. It is also used to calculate content uniformity when the from the assay results only when the dosage form which are having Active Pharmaceutical Ingredient more than 25 % of the excipient used in formulation. This is carried out during chemical analysis.

Uniformity of Content is carried out to check the uniform distribution of the Active Pharmaceutical Ingredient of 10 units from the randomly selected units. This test is carried out mainly when the API content is less than 25 % of Total Formulation. This is carried out on Instrumental Analysis ( HPLC ).