Answer / sonia

PUVA has a definite potential to cause skin cancer, including melanomas. The risk of developing skin cancer is directly related to the amount of energy administered. PUVA will cause photo-aging (dry and wrinkled with pigment alterations called lentigenes) that is unavoidable. If not appropriately monitored, PUVA can produce severe ultraviolet light burns. Occasionally, Oxsoralen can cause nausea so susceptible patients take the drug with food.

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