Does multidrug resistance (mdr) arise by activation of stable genes encoding drug efflux pumps or by mutations of genes encoding other types of transporters in bacterial pathogens?
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Answer Posted / Dhirendra Kumar Awasthi
"Multidrug resistance (MDR) primarily arises through the activation of stable genes encoding drug efflux pumps, also known as multidrug resistance genes (MDRGs). These pumps expel a variety of drugs from the bacterial cell, reducing their effectiveness. However, MDR can also arise due to mutations in genes encoding other types of transporters and through various chromosomal alterations."
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