In sickle cell anemia, a hereditary disease, there is substitution of one amino acid by other in one of the four-polypeptide chains of hemoglobin. In this case, are all of the structural levels of the protein modified?
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Answer Posted / Krati Vishnoi
Yes, the substitution of an amino acid can affect the tertiary structure and possibly the quaternary structure of the protein if it is a part of a multimeric complex. However, the primary and secondary structures are typically not directly affected.
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