will the passage number affect the performance of THP-1
cells?
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Answer Posted / Dharmendra Kumar Kannaujiya
Yes, the passage number can significantly affect the performance of THP-1 cells, a human monocyte cell line. With each passage, cells undergo replication stress that can lead to senescence, reduced proliferation rate, and changes in gene expression profiles. It's essential to maintain low passage numbers (usually below 30) to ensure optimal performance.
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