What is use of acetonitrile compare to methanol in RP-HPLC Method development?
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Answer Posted / Tara Chand Azad
Acetonitrile and methanol are commonly used as organic solvents in Reverse Phase High Performance Liquid Chromatography (RP-HPLC). However, they have different properties that make them suitable for specific applications. Acetonitrile is more polar than methanol and provides stronger interactions with nonpolar analytes, making it a better choice when separating aromatic compounds or compounds with large molecular weights. On the other hand, methanol is less polar and is more effective in separating polar compounds. The choice between acetonitrile and methanol often depends on the specific characteristics of the analyte being separated.
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