What is the idea behind ?weighting? sequences in the
package CLUSTAL W for multiple alignment? How are these
weights calculated?
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Answer Posted / Robin Charaya
Weighting in CLUSTAL W is a method to give more importance to certain types of amino acids or positions during multiple sequence alignment. This helps to improve the accuracy and reliability of the alignments, especially when dealing with sequences that have evolved at different rates. The weights are calculated based on various properties of amino acids such as hydrophobicity, charge, size, etc.
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