Why we selecting 900 ml dissolution medium perticular drug
as per I.P, USP?
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Answer Posted / chetan
Sink condition: maximum daily dose should dissolve in 250mL of Media (it is related to, we are taking dosage form with a glass of water).
If dose is soluble in 250mL of water then developer can select 3X volume i.e 750mL or above.
Gastric Capacity of normal human being is considered aprox 900 to 1000mL so that much volume is selected.
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