Answer Posted / sandeep kale (toronto, canada)

ROI / Sulfated Ash Test is use to find out Inorganic Impurities.
At 600-800°c all the metal salts (Used as a catalyst in formation of Intermediates / API'S)(which are soluble) gets converted in to metal oxides (Insoluble and Highly Non volatile).
And final residue we get , of Metal Oxides which are Inorganic Impurities.
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Home heating oil or furnace oil what is made from? Can (base oil plus diesel/kerosen) = home heating oil?

2163

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in dissolution why pool sample needed? in which type of drug pool sample need?

3170

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in which situation require to use paddle and basket?

729

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How to decide assay range for non pharmacopeial API analysis by HPLC? Could you give me any reference for same e.g Guidelines or Paper publications?

3345

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WHAT IS THE PARAMETER FOR THE SELECTION OF MOBILE PHASE IN HPLC?

1180

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how will you do the prep for unstable componds?

2016

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2. Two grams of Benzoic acid are dissolved in 200 ml of water and extracted with 200 ml of diethyl ether. The distribution coefficient of benzoic acid is 100, and its dissociation constant is 6.5 10-5. Calculate the distribution ratio (D) of benzoic acid at pH 2, 5, and 6. 3. Calculate D at pH 2 to 10 (1 unit apart) in the above problem, and plot D versus pH.

2212

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How can we calculate offset value pH measurment

1497

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If combination product how require to identify which imp is of which api?

834

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why require the ph, buffer during hplc mobile phase?

849

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How to set specification of assay, fisdolution and related substances?

863

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Ph meter can show more than 14 ph reading? Why ph range in between 1 to 14 only?

727

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what is mean by 40 in the dissolution basket mesh size?

775

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if you get peak in blank then what require to do?

963

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In the HPLC Calibration done wavelength accuracy done between 200nm-280nm .but not done remaining 300-400nm not done ?

912

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