water is more polar than acetonitrile.but in reverse phase chromatography peaks elute earlier when we increse Acetonitrile.what is the reason.

Answer Posted / prasad

based on the solubility of the drug.Most of the drugs are insoluble in water

Is This Answer Correct ?    9 Yes 10 No



Post New Answer       View All Answers


Please Help Members By Posting Answers For Below Questions

how to set sample and standard concentration in RS method?

354


what is the extinction coefficient for Indomethacin or at 319nm wave length.

3513


Describe your field experience sample type collected,sample techniques,field measurements taken and equipment used?

2269


in sampling of raw material which side is pasted sampled labels

1242


What is third generation HPLC Columns?

1500






Difference between the quantitative analysis and qualitative analysis?

615


Many times I don't got a caffeine peak in calibration of hplc using guard column ❓

1156


What is the principle of HPLC, GC, LCMS, GCMS,LC QQQ, GC QQQ, LC Q TOF and GC Q TOF. What are the applications and Specificity?

8303


how require to fix the linearity and accuracy cincentration range?

620


Please give idea about method development for cleaning method and how maco level establish

264


I have compare C2H2-air and C2H2-N2O flame AAS on determination calcium. Both use same range of std to plot calibration curve. (2-6ppm) When i measure the sample with phosphate, KCl and LaCl, C2H2-N2O flame give false positive result, around 0.5ppm. When i measure the sample with phosphste, KCl and EDTA. C2H2-N2O flame also give 0.5ppm false positive. But both above mentioned sample would not give false positive when measured by C2H2-air flame. What is the reason?

2965


what is mean by nitrosamine impurities?

533


What is the principle of Thermal conductivity detector and FID?

2251


why are measure gas flow " ml " in Gas chromatography

1148


How to calculation of residual solvent methanol (3000 ppm) standard solution, and how many quantity used of test sample

2522