Answer Posted / ramya sarma

pKa=pH+log [un ionised]/[ionised]
at the half neutralisation point
un ionised concentration= ionised concentration

so pKa=pH+log1
pKa=pH because log1=0

if we didnt adjudt pH +/-2.0 we may get peak split because
for un ionised we get one peak and ionised we get one more
peak

How to set analyticl specification for combination products?

794

---

In which situation we require to prepare the standard solution from sample in Related substance method?

825

---

How to calibration of the uv spectroscopy and its test?

1242

---

Why we used in n-butyl acetate water content terminology while in ethyl acetate we used moisture content terminology?

1904

---

what is the origin to prepare standard operating procedure

2402

---

what type of question will ask in the interview of lab chemist.

3362

---

is it nessesary to do solution stability for 7 days?

817

---

what is impurity profile. how to interpret this impurity profile to a drug product or drug substance.

2680

---

how you determine moist.of NaOH sol or NaOH flacks

2264

---

in which situation ion pair agent require to use?

799

---

What is the principle of Thermal conductivity detector and FID?

2778

---

why multimedia dissolution require to do?

867

---

What is similarity factor and its use in api strength?

1364

---

In BP2013, Loperamid HCl monograph. Assay by titration with 0.1N sodium hydroxide using hydrocloric acid 0.01N and reading the volume added between the 2 points of inflexion. I have a question that if the diluent solvent is ethanol is certainly consumed a amount of volume of titrant, so this volume must be eliminated on the result calculation or not apart from first point which is subtracted above.

3189

---

AT WHAT CONDITIONS WILL YOU ANALYSE A SAMPLE,WHICH ARE PRESERVED AT OTHER THAN THE AMBIENT CONDITIONS?(ie COLD STORAGE SAMPLES BELOW 20* CENTIGRADE?

2113

---