Answer Posted / jagadeeshchandra

#Base line is nothing but the detectors response to the
mobile phase.(gc,hplc)

#Base line should be stable to start a run.

#Un stabilized base line is called as base line noise.

#Base line noise is of many types..
1)Cyclic base line
2)Synchorinise noise
3)Asynchorinise noise
4)Base line drift
5)Spikes
6)Negative peaks
7)No peaks

#Base line noise is attributed due to mobile phase,sample,
system problems.leaks in the system,temperature variations
in lab etc..

what is mean by 40 in the dissolution basket mesh size?

794

---

What is the principle of Thermal conductivity detector and FID?

2737

---

please explain about aluminium hydroxide assay

1137

---

How can we calculate "confidence interval" in analytical method validation? Pl. explain with example.

4285

---

how you determine moist.of NaOH sol or NaOH flacks

2228

---

Which is the highly polar and highly non polar column in HPLC?

2315

---

why should we perform dissolution PVT calibration only by UV spectrometer, not by HPLC ?

1717

---

What is similarity factor and its use in api strength?

1305

---

What is the difference between chromatographic purity and related substances?

1380

---

What is intact assay method development.....?

2673

---

How you develop a method in HPLC?

2624

---

which one is better separation in high pressure liquide chromatogram orlowpressure chromato gram in hplc

2165

---

is it necessary to do HPLC calibration at wavelength 315nm if we are doing analysis at this wavelangth

2180

---

How require to develop GC method? how to select diluent, GAS, column selection and other chromatographic conditions?

738

---

[3/28, 20:52] Manoj P Venkatpurwar: how many impurities require to inject in assay specificity that how we can find out? and in Rs also how?

797

---