How can we konw that the HPLC column is endcapped? Is it
possible to identify visually without COA?
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Answer Posted / subash
The column without endcapping increses silanol activity due
to residual silanols. To know the column is encapped inect
the amytriptyline a basic compound in to the column which
gives the information about peak tailing. If tailing is
more means more silanol activity.
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