Answer Posted / subash
The following reasons are causes of peak tailing
1.Injecting the sample in a solvent significantly stroger
than the mobile phase
2.Interaction of stationary phase silanols with basic
analyte
3.Adsorption of acidic compounds on the stationary phase
4.Sample mass overloaded
5.A void in the column packing bed
| Is This Answer Correct ? | 5 Yes | 0 No |
Post New Answer View All Answers
If we have 5 strength which is not dose proportinate and excipients also diffrent in each strength then how we can proceed for Force degradation? and excipient are same but not dose propotinate the how FD?
why cone formation during dissolution?
how pda detector works over uv?
What is dose dumping? why require to do?
Why use only methanol,used determinationof moisture content not use other solvents
What is split ratio in Gc? Splitless? how requirr to select?
what is mean by ambient temperature?
Why are use silicon oil mr?
In the HPLC Calibration done wavelength accuracy done between 200nm-280nm .but not done remaining 300-400nm not done ?
can i use hplc detector to uplc and why?
we can use expired sample for validation and analyst qualification?
What is control room temperature and which guide line says?
How we choose the mobile phase for method development.?
What is the formula for relative diffrence for standard solution in solution stability in validation?
Why to use propyl paraben in HPLC gradient calibration
