Answer Posted / sridhara h s
1) Check the for loose fittings, check pump for leak, salt
build up in pumping area,
2) If mobile phase contamination or detoriation,
3) If detector is not working properly - weak lamp detector,
4) Any air trapment in the system and as well as in mobile
phase,
5) Air bubles in detector - make purging proprly,
6) If cloumn is leaking silica or packing material passing
through detector.
| Is This Answer Correct ? | 21 Yes | 1 No |
Post New Answer View All Answers
why we use Dichlorobenzene.nitrobezine.t-butyldi sulhate.for calibration of gc Head space
In performance Check of GC Why Hexadecane Peak is ConsideredÂ
In HPLC calibration, caffeine is used as primary standard for wave length calibration due to caffeine is having dual maxima at 273 & 205 nm and one minima at 245 nm. Any body can give reference of these details from any pharmacopeia (with chapter no.) or any other authentic guideline?
what is different when impergnated silica plates are used in separation of azo dyes using column chromatography?
can we use the same detector in HPLC as well GC and what could be the differences we can find in the final chromato graph in any aspects?
analytical method validation require to with respect to release specification or shelf life specification?
acceptance criteria for lod & loq by standard deviation of response and slope??
For standardization of volumetric solutions, acceptance limit for concentration is considered as 10% of nominal concentration and %RSD as NMT 0.2% (for appropriate no. of replicates). But , if %RSD has not met, what should be further action?
what is the origin to prepare standard operating procedure
We use hicrome 10 cxs column in hplc analysis....pls tell me.. what is the meaning of 10 cxs?
what is the principle involved in turbidometry and nephelometry ?
Why we select scan range from higer wavelength to lower wavelength in uv visible spectroscopy and ftir spectroscopy ? .
What are modes of quantification in related substances
Hi sir if any product monograph not given known impurities (may be 5 impurities) specifications then how we require to proceed for inhouse formulation?
we are performed SOR for a particular product the limit is -6 to -10.We face particular bathes it is not meeting the specification.we performed diffrent instrument diffrent analyst we are getting diffrent diffrent results.solvent is dimethyl sulfoxide what could be the reasion