What is the difference b/w OVI Solvents and Residual
Solvents in case of Gas Chromatogaphy and What is its
Detection Limit?
Answer Posted / d.sambireddy
Organic volatile impurities called OVI. Its limit is
very low.
benzene, chloroform, 1,4-dioxane, ethylene oxide, methylene
chloride and trichloroethylene
The above solvents are now included in Residuval solvents
suppose these solvents we are using (or) are not using in
process but we determine the solvents because these sovents
are toxic. its PDE is very low
RS:RESIDUAL SOLVENTS ,Theirs limits r high compared to ovi.
Is This Answer Correct ? | 11 Yes | 7 No |
Post New Answer View All Answers
Which parameter require to do for analytical method equivalency?
what is mean by ambient temperature?
Difference between the quantitative analysis and qualitative analysis?
How we performed the force degradation for drug substance, is any specific guideline is available for each parameter(Acidic, basic, oxidation,heat)? what conditions you mentained for above parameters.
How would you decide dissolution medium for NCE compound of class I drug
How to set analytical specification for combination products?
Why only 1.2 million lux hours require in photostability study?
which one is better separation in high pressure liquide chromatogram orlowpressure chromato gram in hplc
Please tell me about the pH of Polycaboxylic ether is it in the 5-6 range ever or more than 6
what parameters we will consider while developing a HPLC method and how we confirm our HPLC method is valid?
what is definition of validation? which components are followed give detail?
identification is for unknown? qualification for known? reporting for LOQ?
how to qualify the impurity?
If combination product how require to identify which imp is of which api?
what you do when compound having dwel wavelength?