what is the difference between Tailing Factor & Asymmetry
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Answer Posted / saji
Asymmetry
A factor describing the shape of a chromatographic peak.
Theory assumes a Gaussian shape peak that is symmetrical.
The peak asymmetry factor is the ratio (at 10 percent of
the peak height) of the distance between the peak apex and
the back side of the chromatographic curve to the distance
between the peak apex and the front side of the
chromatographic curve. A value >1 is a tailing peak, while
a value <1 is a fronting peak.
Tailing
A peak with an asymmetrical factor of >1. An asymmetrical
peak is the result of a component that is excessively
retarded in eluting. Tailing is caused by sites on the
packing that have a stronger than normal retention for the
solute. A typical example of a tailing phenomenon is the
strong adsorption of amines on the residual silanol groups
of a low coverage reversed-phase packing.
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