Answer Posted / neenie

USP and Pheur (EP) have harmonized the methods. USP
accepts EP method as equivalent. Basically they are the
same tests.

2. Two grams of Benzoic acid are dissolved in 200 ml of water and extracted with 200 ml of diethyl ether. The distribution coefficient of benzoic acid is 100, and its dissociation constant is 6.5 10-5. Calculate the distribution ratio (D) of benzoic acid at pH 2, 5, and 6. 3. Calculate D at pH 2 to 10 (1 unit apart) in the above problem, and plot D versus pH.

2218

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Ratio of Water and Acetonitrile(diluent) is not recommended to use in cleaning method validation,why?

2959

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If change in specification which parameter require to do for validation? if change in chromtographic condition then which parameter? if api change then which parameter? if change composition then which parameter? if old method not work out then whicj parameter? if additional one impurity added then which parameter of validation require to do on above each conditions? elaborate separately

852

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if you have given one product then how you determine the impurity in that?

737

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What is the acceptance criteria for moisture balance when calibrated with sodium sulfate

2038

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how require to set assay concentration for standard and sample?

918

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What is intact assay method development.....?

2659

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EXPLAIN THE CALCULATION PART OF AN KF TITRATOR CALIBRATION WITH SUITABLE EXAMPLE

2634

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Why sometime potassium ortho phosphate mix with acetone use for sample preparation for hplc

1464

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what is the disso medium for tropsiun chloride

2258

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process of Diclofenac sodium,IP.

2207

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what parameters we will consider while developing a HPLC method and how we confirm our HPLC method is valid?

3687

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What is the use of tlc and hplc? And when and where use?

1154

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how to calculate elemental impurities?

1032

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What is the accrptance criteria in RSD for RS method precision on basis of impurity percentages?

820

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