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Answer Posted / madhukar
Collagen has an unusual [[amino acid]] composition and
sequence:
* [[Glycine]] (Gly) is found at almost every third
[[residue (chemistry)|residue]]
* [[Proline]] (Pro) makes up about 9% of collagen
* Collagen contains two uncommon derivative amino acids not
directly inserted during [[translation (genetics)
|translation]]. These amino acids are found at specific
locations relative to glycine and are modified post-
translationally by different enzymes, both of which require
[[vitamin C]] as a [[cofactor (biochemistry)|cofactor]].
** [[Hydroxyproline]] (Hyp), derived from proline.
** [[Hydroxylysine]], derived from [[lysine]]. Depending on
the type of collagen, varying numbers of hydroxylysines
have [[disaccharide]]s attached to them.
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