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How the malaria parasite evades detection by the human
immune system?
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Answer Posted / dr.suhasini bhatnagar
In malaria, Plasmodium falciparum uses various red blood
cell invasion mechanisms to evade the human immune response,
which eventually causes the disease. Antibodies that prevent
P. falciparum from invading red blood cells (erythrocytes)
are believed to be important components of immunity against
malaria. The malaria parasite interferes with the function
of dendritic cells, stopping them from maturing and from
'presenting' antigen to naive T cells. The parasite does not
interfere with the human cells directly. Instead, it
produces proteins that are then found on the surface of the
red blood cell it is hiding within. These proteins bind to a
molecule called CD36, found on the surface of the dendritic
cells (and on the surface of other immune cells).This
binding causes the dendritic cells to become inhibited,
stopping them producing sufficient proteins of their own
required to make prolonged contact with naive T cells. The T
cells become unresponsive and so a successful immune
response is thwarted.
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