Answer Posted / aditi
In purified water the solubility of chloramphenicol is only
0.25%.
Several approaches such as pH adjustment, complexation ,
micellar solubilization , cosolvency were successfully
employed to enhance the solubility. The present market and
official preparations contain chloramphenicol in water, the
pH adjusted with boric acid/borax buffer to enhance to the
required solubility (5 mg/ml). Similarly, when the pH is
raised to 8.6, its solubility reaches to 1%. However, the
stability and activity are much reduced.
Solubility of non-ionizable substances can be enhanced by
the addition of non polar solvents and when mixture of
solvents such as PEG 300 are used along with water, the
technique is generally termed as cosolvency techinque.
Is This Answer Correct ? | 9 Yes | 2 No |
Post New Answer View All Answers
After primary herpetic gingivostomatitis,where will be the herpes virus may remain dormant ?
Explain about semisynthetic penicillins and indicate their uses in therapy.
Explain the degradation of acrylamide?
How to culture virus in primary cell lines?
What is the Problem with a chromogenic Indolyl-L-arabinoside in E .coli?
something About virus purification?
What is the trouble in growing streptococcus species?
What is meant by biotransformation and swertiamarin?
Which are the bacteria or bacterial component that can’t be stained by gram stain?
Why Lactobacilli are considered the most aciduric and acidogenic organisms in the oral cavity ?
what is the protocol for immunoprecipitation of bacterial proteins?
which cultures or subcultures or standards are generally using as a positive control for total aerobic microbial count in API?
Describe Shigella flexneri ?
What would you do if it was a slow day in the lab?
Describe Metal Cylinder Diffusion Method ?