rambabu cherukuri


{ City } hyderabad
< Country > india
* Profession * sr. research associate
User No # 110195
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Total Answers Posted # 6

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Questions / { rambabu cherukuri }
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Answers / { rambabu cherukuri }

Question { 3487 }

if partition coefficient value was positive means, what it
indicates ?


Answer

If it is positive means- more solubility in in organic solvents
If it is 0-1:1
If it is Negative means-more solubility in aqueous

Is This Answer Correct ?    2 Yes 0 No

Question { 10453 }

why we are using buffer solutionas as a mobile phase in hplc.


Answer

suitable buffer will maintain the pH, what we adjusted

Is This Answer Correct ?    2 Yes 1 No


Question { Laurus, 3991 }

What is Log p?


Answer

Log p is the partition coefficient, mainly it indicates the solubility of drug
Log p=1-more in organic soluble
Log p=0-1:1
Log p=-1, more aqueous soluble

Is This Answer Correct ?    3 Yes 0 No

Question { Laurus, 10283 }

How we will choose pH of a mobile phase if analyte pKa value is 4


Answer

above answer is not exactly
pH value will be +/_ ≥2 to Pka of drug

Is This Answer Correct ?    4 Yes 2 No

Question { Celon Labs, 13261 }

why should we calibrate pH meter with 4,9.2 and 7.4 buffers particularly?


Answer

there was nothing particularity in pH meter calibration, as per our utility in lab or products, we will fix those particular points
in my lab, 1.68, 4.00-acid
7.00-Neutral
10.01,12.45-base
and also we can follow as per usp or some other compendial specs

Is This Answer Correct ?    0 Yes 3 No

Question { Cipla, 9658 }

how can you determine a compound acidic or basic?


Answer

by functional group present in the compound structure
eg:
acidic groups are ionisable and protanated or neutral form like CooH, OH, ketone etc (Polar)

Basic drugs are anaionic like NH3, no2 etc (Non-polar)

Is This Answer Correct ?    2 Yes 0 No