Why are use KF reagent to measure water content & why not any other reagent?
Answer / naveen gutta
Advantage of analysis[edit]
The popularity of the Karl Fischer titration is due in large part to several practical advantages that it holds over other methods of moisture determination, including:
High accuracy and precision - typically within 1% of available water, e.g. 3.00% appears as 2.97 - 3.03%.
Selectivity for water
Small sample quantities required
Easy sample preparation
Short analysis duration
Nearly unlimited measuring range (1ppm to 100%)
Suitability for analyzing:
Solids
Liquids
Gases
Independence of presence of other volatiles
Suitability for automation
Linearity - single-point calibration, no calibration curves necessary
In contrast, loss on drying will detect the loss of any volatile substance.
The major disadvantage is that the water has to be accessible and easily brought into methanol solution. Many common substances, especially foods such as chocolate, release water slowly and with difficulty, and require additional efforts to reliably bring the total water content into contact with the Karl Fischer reagents.
| Is This Answer Correct ? | 1 Yes | 0 No |
why single injection in related substance & dissolution but why not in assay ?
0 Answers Getz Pharma Research,
What are the causes ,cure and preventive measures of (a) Diabetes (b)Plague (c)Typhoid (d)Hydrophobia or Rabies
What is meaning of LOD and Water content ?
3 Answers Alembic, Hetero, Lupin, Reddy Labs, Zeiss Pharmaceuticals,
What are different sterilization methods used in laboratory?
1.What is the effect of the OPTIONS statement ERRORS=1?
What are infectious diseases?
What are the different techniques for placing samples in micro-scope?
What is thr instrument used for specific gravity of urine?
if ASO test comes positive,than what would be the solution?
what are elisa tests and pcr tests?
why we have to use particular buffer only for dissolution.
WHAT IS FORCED DEGRADATION STUDy? HOW TO PERFORM FORCED DEGRADATION ON TABLET SAMPLE OR SUSPENSIONS?