what is the relative response factor in related substances?
is it necessary to calculate?
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Answer Posted / prashant dhuri
Response factor = response(in response units)
concentration(in mg/mL)
ž Relative response factor: the ratio of the response
factor of individual related
substance to that of a drug substance to correct for
differences in the response
of related substances and that of the drug substance. It
can be determined using the following equation:
Relative response factor = response factor of individual
related substance
response factor of drug substance
If a linearity curve is constructed for both the related
substance
and the drug substance by plotting the response versus the
concentration,
the relative response factor can also be determined by
Relative response factor = sloperelated substance
slopedrug substance
The relative response factor (RRF) can be used to
correct for differences in relative response between the
related substances and
the drug substance.
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